Evodia rutaecarpa (Juss) Benth is a commonly used Chinese herbal medicine. Studies have found that Evodia Extract has the functions of expanding blood vessels, lowering blood pressure, strengthening the heart, antidiarrheal, uterine contraction, insecticidal, antibacterial, antiviral, antiulcer, anticholinesterase and inducing apoptosis of human cervical cancer HeLa cells. External treatment of aphthous, high blood pressure and so on.
The main chemical constituents of Evodia extract
The main components of Evodia are alkaloids, bitter substances, volatile oils, terpenes, flavonoids, coumarin, steroids, lignans and other components.
Pharmacological effects of the active ingredients of Evodia extract
Pharmacological effects of Evodia alkaloids
Evodiamine is unstable to light, heat, acid and alkali. When the temperature exceeds 60°C and the pH is <5 or >9, the structural change occurs. Pharmacological activity experiments show that it has obvious cell damage, cardiac, analgesic, antihypertensive, antitumor, antibacterial and uterine contraction effects.
Evodia alkaloids can dilate blood vessels and lower blood pressure
Strengthen the heart, protect the heart and anti-arrhythmia
Dilate blood vessels and regulate blood pressure
Evodia alkaloids have anti-ulcer effect
Evodia alkaloids have different degrees of inhibition on ulcers.
Antibacterial effects of Evodia alkaloids
Evodia alkaloids quinolone alkaloids have inhibitory effects on Helicobacter pylori (HP), which can cause gastritis and gastric cancer. It is one of the important means for the treatment of gastric and duodenal diseases.
Analgesic and anti-inflammatory effects of Evodia alkaloids
The nociceptive response of evodiamine was similar to that of the anti-nociceptive control drug aspirin. Evodiamine has a specific blunting effect on sensory nerves. Evodiamine exerts its analgesic effect by blunting pain sensory nerves.
Antitumor Activity of Evodia alkaloids
Antitumor effect is one of the main pharmacological effects of evodiamine. Numerous cell experiments and animal experiments have confirmed the antitumor activity of evodiamine. It has a wide range of anti-tumor properties and is a promising new natural anti-cancer drug. Studies have found that evodiamine can induce tumor cell apoptosis, hinder the cell cycle and inhibit tumor tissue invasion and metastasis.
Studies have shown that Evodia alkaloids can induce apoptosis of human uterine cancer cells.
Weight loss and effects on bronchial smooth muscle of Evodia alkaloids
Evodiamine is a novel non-stimulatory vanilloid receptor agonist. Similar to the anti-obesity effect of capsaicin. It simultaneously induces the production and dissipation of heat, preventing the accumulation of peri-visceral fat and weight gain.
Activity of other components of Evodia extract
Caryophyllene and geraniol in the volatile oil of Evodia has sedative, antiasthmatic, antibacterial, antiviral, antitumor and other effects.
Evodia bitterin can enhance the digestive function of the gastrointestinal tract, and also contains volatile oil, which inhibits abnormal fermentation in the intestine.
Chlorogenic acid is beneficial to the biliary function of the digestive system, has the effect of stopping bleeding and increasing the number of white blood cells in the blood system, and has a hemostatic effect on menorrhagia in the reproductive system and functional uterine bleeding.
Conclusion
Evodia is a traditional Chinese herbal medicine. Chinese herbal medicine has been used to prevent and cure diseases since ancient times. Evodia alkaloids are the main active substances, which have various pharmacological activities such as anti-tumor, anti-nociception, weight loss, protection of the heart, and lowering blood pressure. Evodia extract is a natural medicine with broad development prospects.
